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Antihistamines like Zyrtec and Claritin are designed to calm the histamine reaction your body has when it’s exposed to an allergen.

Serkalem Mekonnen, RN, BSN, MPH Certified Specialist in Poison Information Case 1: A 13-month-old 22-lb boy was discovered by his mom playing with an empty bottle of Unisom® gelcaps (diphenhydramine 25 mg).Zyrtec and Claritin have very few side effects and are generally recognized as safe for most people. Zyrtec can cause sleepiness, but only in some people.Take it for the first time when you will be at home for a few hours in case it makes you sleepy.Histamine produces increased vascular permeability, causing fluid to escape from capillaries into tissues, which leads to the classic symptoms of an allergic reaction — a runny nose and watery eyes. Antihistamines suppress the histamine-induced wheal response (swelling) and flare response (vasodilation) by blocking the binding of histamine to its receptors or reducing histamine receptor activity on nerves, vascular smooth muscle, glandular cells, endothelium, and mast cells.Itching, sneezing, and inflammatory responses are suppressed by antihistamines that act on H1-receptors.

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